I wonder if some of the dose-response variability reported for 2C-T-7
may reflect unreliable absorption via different routes.  Whereas,
for example, LSD seems to pass into the body via almost any route,
2C-T-7 isn't so readily accepted.  Here are some accounts of experiences
with different routes.

1) orally - once about 25mg, swallowed immediately, produced no noticeable
effects for 3 hours, then some effects which were muddled compared to
other sessions.  There was some abdominal discomfort.
Other oral sessions with 10-20mg were more successful, but involved
delaying swallowing for between 8 and 20 minutes.
2) sub(&super)lingually - on one occasion as little at 10mg produced
relatively strong effects (++) with an onset curve similar to LSD.  This
route is problematic since the material tends to elicit profuse saliva
which makes it difficult not to swallow.  Staggering the dose over an hour
can be helpful in keeping down the saliva and thus maximizing absorption
through the mouth.
3) nasally - 10mg produced strong effects within 20 minutes, and the
effect seemed qualitatively better than with the oral route.  Also
duration of effect was diminished.  However the discomfort to the nasal
mucosa was severe and lasted at least 30 minutes.  This seems easily 100
times as irritating as M - much greater than the potency ratio.
(500mg of M nasally is surprisingly smooth)
4) rectally - 25mg taken in a water enema and held 40 minutes produced
some irritation but no noticeable effects.  This experiment was incon-
clusive since the material could have gotten stuck to the sides of the
containers used.  (This route has proved effective with several
natural substances including HBWR seed juice.)
5) transdermally - 25mg was mixed with a small amount of skin cream
and spread onto a 2x2" patch of skin, taped over with plastic and left
for 2 hours.  Thereafter there was no noticable residue on the skin.
No effects were noticed.

conclusions:
* Of all the methods, sublingual seems to provide the best combination of
efficacy, reliability, and painlessness.
* 2C-T-7 seems to have a harder time entering the body than most of the
better known entheogens, many of which are effective transdermally.
(Are any of the other PEAs known to be effective transdermally?)
I would guess it is more resistant to entry than many of its arguably
closer-to-nature synthetic relatives, such as Proscaline, 2C-E, TMA-2,
or MMDA, or even DOM or MDMA.

-jim